Eye (London, England) · 2005
Vitreous leptin levels in retinal disease.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Maberley D, Cui J Z, Matsubara J A
Аннотация
BACKGROUND/AIMS: The purpose of this study was to investigate the relationship between vitreous leptin levels and retinal diseases.
METHODS: Levels of vitreous leptin were evaluated in proliferative diabetic retinopathy (PDR) and a variety of other retinopathies including: macular disease, neovascular maculopathies, primary retinal detachments, and vascular occlusive disease.
RESULTS: In patients with PDR (N=7), the average vitreous level of leptin (37.4 ng/ml) was significantly higher than that in patients with PVR (<1.0 ng/ml, P<0.05). Vitreous leptin level in patients with PVR or macular disease (N=18), with or without diabetes, was not significantly different from the control subjects who had retinal detachment only (N=7).
CONCLUSION: The results show that the leptin level in vitreous taps is elevated in PDR. We suggest that leptin plays an active role in PDR.
METHODS: Levels of vitreous leptin were evaluated in proliferative diabetic retinopathy (PDR) and a variety of other retinopathies including: macular disease, neovascular maculopathies, primary retinal detachments, and vascular occlusive disease.
RESULTS: In patients with PDR (N=7), the average vitreous level of leptin (37.4 ng/ml) was significantly higher than that in patients with PVR (<1.0 ng/ml, P<0.05). Vitreous leptin level in patients with PVR or macular disease (N=18), with or without diabetes, was not significantly different from the control subjects who had retinal detachment only (N=7).
CONCLUSION: The results show that the leptin level in vitreous taps is elevated in PDR. We suggest that leptin plays an active role in PDR.