Bilateral ovarian carcinosarcoma - A rare and aggressive malignancy: Case report.

INTRODUCTION AND

IMPORTANCE

Carcinosarcoma of the ovary also referred to as malignant mixed Müllerian tumor (MMMT), is a rare and aggressive gynecological malignancy characterized by the presence of both epithelial and mesenchymal components. It accounts for <5 % of ovarian cancers, presenting significant diagnostic and therapeutic challenges due to its high-grade nature and poor prognosis.

CASE PRESENTATION: We describe the case of a 75-year-old postmenopausal woman who presented with a three-month history of abdominal distension, pelvic pain, light vaginal bleeding, nausea, and early satiety. Imaging revealed a complex, multiloculated mass in the right adnexa with ascitic fluid. Elevated CA-125 levels supported the suspicion of malignancy. The patient underwent optimal surgery, including total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and appendectomy. Histopathological examination confirmed high-grade bilateral ovarian carcinosarcoma with a biphasic pattern of carcinomatous and sarcomatous components.

CLINICAL DISCUSSION: Ovarian carcinosarcoma is a rare and highly aggressive malignancy with a clinical presentation similar to other ovarian cancers. Imaging and tumor markers lack specificity, and definitive diagnosis relies on histopathology. Optimal surgery remains the cornerstone of management, followed by adjuvant chemotherapy. The prognosis is poor, with high recurrence rates and limited therapeutic options.

CONCLUSION

Ovarian carcinosarcoma represents a diagnostic and therapeutic challenge due to its aggressive nature and rarity. Early surgical intervention and multidisciplinary management are critical to improve patient outcomes. This case highlights the importance of heightened clinical awareness and histopathological confirmation in addressing this rare gynecological malignancy.