Fuchs' heterochromic cyclitis: an electron microscopy study.

Electron microscopy and computerised image analysis of iris biopsies in five cases of Fuchs' heterochromic cyclitis showed that depigmentation was due to significant reduction in deep stromal melanocyte numbers and a decrease in melanosomal size, in the presence of more mast cells and an infiltrate of plasma cells and lymphocytes. Anterior border cells appeared sparse and their melanosomes showed similar differences when compared to five normally pigmented controls. Pigment epithelium melanosomes did not alter in size.