[The chronopharmacology of the antidepressants].

The conception of the specific activity of antidepressants is considered from the chronobiological positions. Depression can be based on phasic dissociation between different periods and first of all circadian fluctuation of some physiological functions. Various antidepressants modified biorhythms and promoted their resynchronization. This action probably depended on its influence on the activity of the cerebral pacemaker structures (suprachiasmatic nuclei, hypothalamus and pineal gland).