Immunohistochemical demonstration of human circulating antibodies against lamina propria of gastric mucosa.

This paper describes a fluorescent pattern of human antibodies circulating in the serum of a 57 year old patient with lymphogranulomatosis. Following incubation with different FITC-labeled anti-human IgG sera including F(ab)2-fragments and with antibodies to human IgA, IgM, IgD, IgE as well as guinea pig serum and FITC-labeled anti-guinea pig serum (for proof the complement binding), it can be assumed that this is a non complement binding IgG antibody directed first of all against the rat gastric mucosal lamina propria (in the cardia and corpus and weaker in the pylorus region). The titre was 1:640. 1:80 diluted serum did not react with duodenum, jejunum, colon, tongue, oesophagus, parotid gland, trachea, lung, heart, diaphragm, liver, spleen, or kidneys. Among others, the species specificity and the antigen binding sides remain to establish.