Anticancer research · 2004
A report of three patients treated with immunocell therapy with imatinib mesylate.
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Kaneko Toru, Goto Shigenori, Kushima Yoshiaki, Miyamoto Yoju, Eriguchi Masazumi, Nieda Mie, Egawa Koji
Аннотация
BACKGROUND: Immunocell therapy has been applied to patients with refractory cancer in clinical trials or as an unconventional cancer therapy, however the efficacy is still limited. To improve this efficacy, a combination therapy may be beneficial. Molecularly-targeted therapy acts directly on neoplasm cells to suppress their growth without causing myelosuppression.
CASE REPORT: Recently, we encountered three patients treated by immunocell therapy with imatinib mesylate (Glivec). One patient was diagnosed as having Philadelphia chromosome (Ph) (+) acute lymphoblastic leukemia (ALL) and had a relapse-free survival of more than 24 months. The other two were diagnosed as having GIST; a partial response was observed in one which lasted more than 21 months, while the other's disease has been stabilized for more than 25 months. No side-effects were observed, other than those mentioned in the directions for the use of imatinib.
CONCLUSION: Immunocell therapy may have a potent therapeutic effect when used in combination with molecularly-targeted therapy, which has few side-effects.
CASE REPORT: Recently, we encountered three patients treated by immunocell therapy with imatinib mesylate (Glivec). One patient was diagnosed as having Philadelphia chromosome (Ph) (+) acute lymphoblastic leukemia (ALL) and had a relapse-free survival of more than 24 months. The other two were diagnosed as having GIST; a partial response was observed in one which lasted more than 21 months, while the other's disease has been stabilized for more than 25 months. No side-effects were observed, other than those mentioned in the directions for the use of imatinib.
CONCLUSION: Immunocell therapy may have a potent therapeutic effect when used in combination with molecularly-targeted therapy, which has few side-effects.