[sCD44 in peripheral blood cultures of mononuclear cells and in the serum of patients with B-cell chronic lymphocytic leukemia].

The aim of this study was to estimate the ability of peripheral blood mononuclear cells to release of soluble CD44 standard (sCD44st) compared to concentration in the serum of patients B cell chronic lymphocytic leukemia. The results showed the decrease of secretion of sCD44 by leukaemic cells in studied patients. There was no significant differences between patients with I and III stage according to Rai classification. In the serum of patient group we found higher concentrations of sCD44 in comparison with control group. Lack correlation between the concentrations of sCD44 in the cultures and serum suggest that other than leukaemic cells may be significant source of this molecule in patients with B cell chronic lymphocytic leukemia.