[Experimental study of the efficacy and clinical use of Perfoost in cases of defect substitution and correction of face supporting tissues].

Positive properties and perspectivity of demineralized osseous allogenic implants were pointed to. Experimental model of primary osseous plasty of mandible defects was described. The comparison of character and pace of reparative osteogenesis in experimental bone defects with Perfoost use and without transplantation was done. Perfoost had expressed osteoinductive and osteoconductive properties providing quicker reparative osteogenesis. In clinic osseous plasty operations of upper, middle and lower parts of face were done with the use of Perfoost. All in all 14 operations in 13 patients were conducted: in 3 patients - contour plasty of frontal region of head, in 5 patients- deformation correction of zygomatic region, lower edge and bottom of eye-socket; in 5 patients - defect substitution of mandible body and branch of the 8-10 cm length (in combination with titanium plates). In 2-3 months after operation the first signs of transplant rebuilding were detected during X-ray control. The expressed rebuilding of Perfoost with its substitution by newly formed bone was seen in 1-1.5 year. No complications followed, terms of observation - up to 8 years.