Basic and clinical neuroscience · 2020
The Effects of 3,4-methylenedioxymethamphetamine on Neurogenesis in the Hippocampus of Male Rats.
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Soleimani Asl Sara, Ghasemi Moravej Fahimeh, Kowsari Golshad, Farhadi Mohammad Hassan, Pourhaydar Bagher, Ghasemi Hamidabadi Hatef, Mehdizadeh Mehdi
Аннотация
INTRODUCTION: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats.
METHODS: Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/ kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses.
RESULTS: MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related.
CONCLUSION: MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.
METHODS: Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/ kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses.
RESULTS: MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related.
CONCLUSION: MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.