Difference in characteristics and outcomes of basaloid squamous cell carcinoma and squamous cell carcinoma, usual type in cervix: A population-based study from SEER 18 database.

AIM: Cervical basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma with little recognition. Our objective was to identify difference in characteristics and outcomes between BSCC and squamous cell carcinoma, usual type (SSC, UT).

METHODS

A total of 32 BSCC patients and 6387 SCC, UT patients, diagnosed from 2004 to 2014, were identified using the Surveillance, Epidemiology, and End Results database.

RESULTS

More BSCC patients presented with older age as compared to SCC, UT (patients over 40 years old: 87.5% vs 60.5%, P  < .01). Univariate survival analysis shows that overall survival (OS) and disease-specified survival (DSS) in the BSCC group were slightly better than SCC, UT group, but without statistical significance. Furthermore, BSCC presented similar prognosis in both DSS and OS compared to SCC, UT when matching other parameters with the propensity score matching methods.

CONCLUSION

BSCC tends to appear in older people. However, BSCC appears to carry a similar prognosis compared to SCC, UT.