Chemistry (Weinheim an der Bergstrasse, Germany) · 2018
From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Svezhentseva Ekaterina V, Vorotnikov Yuri A, Solovieva Anastasiya O, Pozmogova Tatiana N, Eltsov Ilia V, Ivanov Anton A, Evtushok Darya V, Miroshnichenko Svetlana M, Yanshole Vadim V, Eling Charlotte J, Adawi Ali M, Bouillard Jean-Sebastien G, Kuratieva Natalia V, Fufaeva Maria S, Shestopalova Lidiya V, Mironov Yuri V, Efremova Olga A, Shestopalov Michael A
Аннотация
Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6 I8 }(DMSO)6 ](NO3 )4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.