PM & R : the journal of injury, function, and rehabilitation · 2025
A single-arm feasibility study protocol for a multiphasic multimodal exercise prehabilitation intervention in individuals receiving allogeneic stem cell transplant.
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Wagoner Chad W, Daun Julia T, Cannon Jocelyn, Danyluk Jessica, Langelier David, Francis George J, Culos-Reed S Nicole, Perry Sarah
Аннотация
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can be a life-saving treatment for individuals diagnosed with acute leukemia. However, allo-HSCT can lead to adverse effects, such as reduced physical function. Exercise has demonstrated benefits in post-allo-HSCT recovery, but feasibility issues persist in tailored prehabilitation interventions.
OBJECTIVE: To present a multiphasic exercise prehabilitation protocol.The study aims to assess feasibility, safety, and impact while establishing screening and referral pathways to community-based exercise oncology resources.
DESIGN: Single arm feasibility study.
PARTICIPANTS: Individuals diagnosed with acute leukemia and eligible for allo-HSCT will be recruited for the study.
INTERVENTION: Multimodal exercise and health behavior change support that will span across the allo-HSCT timeline (ie, pre-, during, and post-transplant phases). Clinical exercise physiologists trained in exercise oncology and health behavior change will deliver the intervention.
MAIN OUTCOME MEASURES: Assessment of physical function, self-reported and objective physical activity, quality of life, fatigue, anxiety, depression, and symptom burden across four timepoints (baseline, pre-transplant, post-transplant inpatient recovery, and post-transplant outpatient recovery).
CONCLUSIONS: This study is designed to address current limitations in prehabilitation literature specific to individuals with acute leukemia receiving allo-HSCT. In turn, this study may offer an approach to maintain or improve physical function and quality of life throughout the transplant continuum.
OBJECTIVE: To present a multiphasic exercise prehabilitation protocol.The study aims to assess feasibility, safety, and impact while establishing screening and referral pathways to community-based exercise oncology resources.
DESIGN: Single arm feasibility study.
PARTICIPANTS: Individuals diagnosed with acute leukemia and eligible for allo-HSCT will be recruited for the study.
INTERVENTION: Multimodal exercise and health behavior change support that will span across the allo-HSCT timeline (ie, pre-, during, and post-transplant phases). Clinical exercise physiologists trained in exercise oncology and health behavior change will deliver the intervention.
MAIN OUTCOME MEASURES: Assessment of physical function, self-reported and objective physical activity, quality of life, fatigue, anxiety, depression, and symptom burden across four timepoints (baseline, pre-transplant, post-transplant inpatient recovery, and post-transplant outpatient recovery).
CONCLUSIONS: This study is designed to address current limitations in prehabilitation literature specific to individuals with acute leukemia receiving allo-HSCT. In turn, this study may offer an approach to maintain or improve physical function and quality of life throughout the transplant continuum.