AIDS (London, England) · 2002
Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression.
СтатьяПоддержка исследования: вне правительства СШАПоддержка правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Appay Victor, Hansasuta Pokrath, Sutton Julian, Schrier Rachel D, Wong Joseph K, Furtado Manohar, Havlir Diane V, Wolinsky Steven M, McMichael Andrew J, Richman Douglas D, Rowland-Jones Sarah L, Spina Celsa A
Аннотация
DESIGN: Antiretroviral therapy (ART) currently represents the best way to avert the lethal consequences of chronic persistent HIV-1 infection. It leads to significant reductions of plasma viremia, often to undetectable levels, but it can also be linked with the reduction and disappearance of detectable HIV-specific CD8 T-cell responses.
RESULTS: Here we describe a group of patients in whom ongoing replication of HIV, particularly transcription of Nef mRNA species, was detected despite prolonged and clinically successful antiretroviral treatment. Modest, but significant, numbers of HIV-specific CD8 T cells and CD4 T-cell responses were found in these subjects, with the strongest responses directed towards Nef epitopes. Detailed phenotypic analysis of the HIV-specific CD8 cells demonstrated low perforin levels and persistent expression of CD27, a phenotype associated with incomplete differentiation of cytotoxic T lymphocytes (CTL).
CONCLUSION: This immature CTL phenotype has been described previously in association with chronic HIV disease, but its continued persistence is surprising in the setting of prolonged viral suppression on therapy and the presence of HIV-specific CD4 cell activity.
RESULTS: Here we describe a group of patients in whom ongoing replication of HIV, particularly transcription of Nef mRNA species, was detected despite prolonged and clinically successful antiretroviral treatment. Modest, but significant, numbers of HIV-specific CD8 T cells and CD4 T-cell responses were found in these subjects, with the strongest responses directed towards Nef epitopes. Detailed phenotypic analysis of the HIV-specific CD8 cells demonstrated low perforin levels and persistent expression of CD27, a phenotype associated with incomplete differentiation of cytotoxic T lymphocytes (CTL).
CONCLUSION: This immature CTL phenotype has been described previously in association with chronic HIV disease, but its continued persistence is surprising in the setting of prolonged viral suppression on therapy and the presence of HIV-specific CD4 cell activity.
Предметные рубрики MeSH
Anti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD28 AntigensCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCohort StudiesHIV AntigensHIV InfectionsHIV Protease InhibitorsHIV-1HumansImmunophenotypingIndinavirInterferon-gammaLamivudineMembrane GlycoproteinsPalatine TonsilPerforinPore Forming Cytotoxic ProteinsRNA, ViralReverse Transcriptase InhibitorsTime FactorsTreatment Outcome