First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids.

OBJECTIVE

To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids.

DESIGN

Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials.

SETTING

Academic hospital.

PATIENT(S): Among the 52 patients, 21 wished to conceive upon treatment completion.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): Pregnancy rate and live birth rate.

RESULT(S): Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy.

CONCLUSION(S): We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.