Current topics in medicinal chemistry · 2026
Cosmetic Products Containing Rutin: A Systematic Review of Patents from 2014 to 2024.
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Andréa da Silva Maria, Moraes Valéria Regina de Souza, Amancio de Jesus Raphael, da Silva José Michael, Correa Heloyza Stefanny de Jesus, Araújo Lorena Cristina Santos
Аннотация
INTRODUCTION: Rutin is a natural flavonoid with several validated benefits for cosmetic use and has been increasingly incorporated into cosmetic and dermocosmetic formulas, especially for its antioxidant potential.
METHODS: A search for patents on the use of rutin in cosmetics was conducted at the European Patent Office (EPO), the World Intellectual Property Organization (WIPO), and the National Institute of Intellectual Property (INPI-Brazil). The search strategy used (i) "rutin" AND (ii) "Cosmetics" OR "Skin Cream" OR "Cosmeceuticals" AND "A61K8" OR "C07H17".
RESULTS: A total of 38 patents were selected, 27 of which emphasized the anti-wrinkle and/or antiaging, sunscreen, and antioxidant effects of their formulations. Fifteen patents reported the botanical origin of the rutin used, highlighting the growing interest in developing new cosmetics from different plant sources.
DISCUSSION: It has been observed that cosmetic compositions containing rutin can combine natural and synthetic active ingredients to achieve synergistic effects. The use of pharmaceutical technologies and structural modifications to the rutin molecule has been reported, including polyglycosylated rutin, troxerutin, and rutin hydroxycinnamate, to improve the molecule's physicochemical properties.
CONCLUSION: Structural modifications to rutin can optimize its effects, and the main technologies described in the patents, such as microencapsulation and nanoliposomes, aim to improve the efficacy of the active ingredients, facilitating their application in cosmetic formulations in both cases. Considering this, we emphasize the potential of local flora as promising sources for cosmetic development and research.
METHODS: A search for patents on the use of rutin in cosmetics was conducted at the European Patent Office (EPO), the World Intellectual Property Organization (WIPO), and the National Institute of Intellectual Property (INPI-Brazil). The search strategy used (i) "rutin" AND (ii) "Cosmetics" OR "Skin Cream" OR "Cosmeceuticals" AND "A61K8" OR "C07H17".
RESULTS: A total of 38 patents were selected, 27 of which emphasized the anti-wrinkle and/or antiaging, sunscreen, and antioxidant effects of their formulations. Fifteen patents reported the botanical origin of the rutin used, highlighting the growing interest in developing new cosmetics from different plant sources.
DISCUSSION: It has been observed that cosmetic compositions containing rutin can combine natural and synthetic active ingredients to achieve synergistic effects. The use of pharmaceutical technologies and structural modifications to the rutin molecule has been reported, including polyglycosylated rutin, troxerutin, and rutin hydroxycinnamate, to improve the molecule's physicochemical properties.
CONCLUSION: Structural modifications to rutin can optimize its effects, and the main technologies described in the patents, such as microencapsulation and nanoliposomes, aim to improve the efficacy of the active ingredients, facilitating their application in cosmetic formulations in both cases. Considering this, we emphasize the potential of local flora as promising sources for cosmetic development and research.