Catecholaminergic mechanisms mediate hypothermia-induced elevations in pineal gland N-acetyltransferase in neonatal rats.

The newly born of many mammalian species are ectothermic, and it is possible that biochemical processes important for the metabolism of endocrine hormones might vary with alterations in the environmental temperature. Temperature-induced fluctuations in pineal gland N-acetyltransferase activity were investigated in 4-, 12-, and 20-day-old rats placed for 4 hr in 23 or 34 degrees C environments. Enzyme activity increased dramatically in ectothermic 4- and 12-day-old animals exposed to the 23 degrees C environment, but not in endothermic 20-day-old rats. The elevations in daytime pineal gland NAT activity seen in cold-exposed animals were absent in rats previously subjected to chemical sympathectomy induced by 6-hydroxydopamine, or in animals treated with the beta-noradrenoceptor antagonist drug propranolol. Catecholaminergic nerves and beta-noradrenoceptors known to be important for light-induced changes in mammalian pineal gland biochemistry also appear essential for environmental temperature-dependent elevations in neonatal pineal N-acetyltransferase activity.