Effect of nolinium bromide, cimetidine, and oxyphencyclimine on gastric hypersecretion induced by some secretagogues in the rat.

Gastric hypersecretion was induced in the pylorus-ligated rat by histamine, pentagastrin, carbachol, or insulin following the peroral administration of either nolinium bromide, a new non-anticholinergic antisecretory drug, cimetidine, an H2-histamine receptor antagonists, or oxyphencyclimine hydrochloride, a specific anticholinergic drug. Nolinium bromide cimetidine or oxyphencycline. Nolinium bromide and cimetidine weakly antagonized hypersecretions in response to carbachol and to insulin while oxyphencyclimine caused profound antagonism. It was concluded that there was incomplete parallelism in inhibitory efficacy among the three antagonist drugs suggesting that their modes of action in blocking gastric hypersection differed. The findings with nolinium bromide were consistent with its lack of specific anticholinergic action and in keeping with its gastric acid antisecretory activity.