Endometrial metastasis of cutaneous melanoma - A case-report bearing diagnostic difficulties -.

OBJECTIVE

To report a rare case of endometrial metastasis of cutaneous malignant melanoma, mimicked by histologically xanthomatous lesion. Only about ten other cases of endometrial metastasis of this malignancy have been reported previously. -

DESIGN

Case report. -

PATIENT: A 60 year old female. -

MAIN OUTCOME MEASURE: Fractionated curettage and immunohistologically examination of the tissue. -

RESULTS

Due to xanthomatous regressive changes of the metastatic tissue, difficulties in the histological confirmation as a metastasis of an unpigmented malignant melanoma occurred. But immunohistological staining showed positivity for S-100 and MART-1, as did the primary tumour. -

CONCLUSIONS

If atypical bleeding in patients with known malignant melanoma of the skin occur endometrial metastasis should be excluded by gynaecologists.