Ginekologia polska · 1998
[The effects of heparin on intrauterine arteries of the human non-pregnant uterus: I. The action of clinically administered heparin].
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Litorowicz A, Laudańska H, Kostrzewska A
Аннотация
OBJECTIVE: Our purpose was to study the action of commercial unfractionated heparin on small human myometrial arteries, in vitro.
MATERIAL AND METHOD: Pieces of myometrial arteries, about 1 mm. in external diameter, were obtained from premenopausal women undergoing hysterectomy. Responses of arteries to K(+)-depolarisation and vassopressin were recorded under isometric condition. Free calcium concentration was determined with ion-selective electrode.
RESULTS: Commercial heparin did not change basal tension of myometrial strips. Depolarised K+ strips were relaxed by heparin in concentration-dependent manner. Inhibition of NO synthase or endothelium denudation do not significantly change the reaction to heparin of strips precontracted with K(+)-depolarisation. There was a time-dependent reduction of the arterial response to vasopressin after incubation with heparin. The calcium ion chelation caused by heparin at concentrations up to 220 IU/mL did not account for the relaxation of uterine arteries.
CONCLUSION: Our results suggest that clinically observed hypotensive effect of the commercial heparin is caused by its direct action on arterial smooth muscle.
MATERIAL AND METHOD: Pieces of myometrial arteries, about 1 mm. in external diameter, were obtained from premenopausal women undergoing hysterectomy. Responses of arteries to K(+)-depolarisation and vassopressin were recorded under isometric condition. Free calcium concentration was determined with ion-selective electrode.
RESULTS: Commercial heparin did not change basal tension of myometrial strips. Depolarised K+ strips were relaxed by heparin in concentration-dependent manner. Inhibition of NO synthase or endothelium denudation do not significantly change the reaction to heparin of strips precontracted with K(+)-depolarisation. There was a time-dependent reduction of the arterial response to vasopressin after incubation with heparin. The calcium ion chelation caused by heparin at concentrations up to 220 IU/mL did not account for the relaxation of uterine arteries.
CONCLUSION: Our results suggest that clinically observed hypotensive effect of the commercial heparin is caused by its direct action on arterial smooth muscle.