Peripapillary Choroidal Neovascularization in Adults: Spectrum of Etiologies and Clinical Features.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Vallino Veronica, Porreca Annamaria, Bandello Francesco, Batlle-Ferrando Sofia, Bernal-Morales Carolina, Boscia Francesco, Breazzano Mark P, Bucceri Vanda, Chaundhary Varun, Chhablani Jay, Cicinelli Maria Vittoria, Couturier Aude, Dolz-Marco Rosa, Sadeghi Elham, Elkobi Tal, Eller Andrew W, Gallego-Pinazo Roberto, Cheung Chui Ming Gemmy, Kapoor Saloni, Melgar Sandra, Montero Javier, Peronetti Mario, Pignataro Maria Grazia, Puligheddu Stefano, Termite Alba Chiara, Viggiano Pasquale, Vujosevic Stela, Zarranz-Ventura Javier, Zur Dinah, Reibaldi Michele, Borrelli Enrico
Аннотация
METHODS: This multicenter retrospective case series included 156 eyes of 138 treatment-naïve patients with peripapillary CNV from 12 tertiary centers. Peripapillary CNV was defined as sub-RPE or subretinal neovascularization within one disc diameter of the optic disc. Multimodal imaging (optical coherence tomography [OCT], fluorescein and indocyanine green angiography, and/or OCT angiography) was used to confirm CNV and etiology. Baseline OCT features included CNV type, exudation pattern, foveal involvement, peripapillary location, and distance to the disc. Longitudinal OCT and best-corrected visual acuity (BCVA, logMAR) were analyzed when available. Management followed routine clinical practice with variable administration of anti-VEGF therapy. Regression models and a conditional inference tree assessed predictors of diagnosis and visual outcome.
RESULTS: The most common etiologies were AMD (51.9%), pachychoroid disease (27.6%), and angioid streaks (6.4%). CNV most frequently involved the temporal peripapillary quadrant (84.6%). Aneurysmal type 1 CNV predominated in pachychoroid disease, whereas type 2 CNV was more common in other etiologies. Baseline BCVA was worse in AMD and angioid streaks and was independently associated with underlying disease and foveal involvement. The Conditional Inference Tree associated age >71 years and nonaneurysmal type 1 or type 2 CNV with AMD.
CONCLUSIONS: Peripapillary CNV most commonly arises from AMD and pachychoroid disease. Simple clinical and imaging features can assist etiological classification and visual prognostication in clinical practice.