Galanin receptor binding sites in the temporal and occipital cortex are minimally affected in Alzheimer's disease.

Galanin receptor binding sites were examined in the inferior temporal and medial occipital gyri of patients with Alzheimer's disease (AD) and matched control subjects using quantitative autoradiography. In the inferior temporal gyrus, galanin binding was reduced selectively in layers V-VI of the AD cases compared to controls, the magnitude of the reduction (45%) being similar to that of choline acetyltransferase activity (40%) in this region. In the medial occipital gyrus, galanin binding in the AD cases was not different from controls in any cortical layer despite a reduction in choline acetyltransferase activity. Galanin binding did not correlate with the densities of neuritic plaques in either temporal or occipital gyri. Thus, despite a significant cortical cholinergic deficit in AD, there is an anatomically selective reduction of cortical galanin receptor binding sites suggesting that the majority of galanin receptors are not located on cholinergic terminals in the human cerebral cortex.