Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
Role of m6A modification in immune microenvironment of digestive system tumors.
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Li Chao, Zhu Mengqi, Wang Jiajia, Wu Hengshuang, Liu Yameng, Huang Di
Аннотация
Digestive system tumors are huge health problem worldwide, largely attributable to poor dietary choices. The role of RNA modifications in cancer development is an emerging field of research. RNA modifications are associated with the growth and development of various immune cells, which, in turn, regulate the immune response. The majority of RNA modifications are methylation modifications, and the most common type is the N6-methyladenosine (m6A) modification. Here, we reviewed the molecular mechanism of m6A in the immune cells and the role of m6A in the digestive system tumors. However, further studies are required to better understand the role of RNA methylation in human cancers for designing diagnostic and treatment strategies and predicting the prognosis of patients.