Cancer investigation · 2018
Radiotherapy for Melanoma with Perineural Invasion: University of Florida Experience.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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История · было → стало
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Zhu Simeng, Mendenhall William M
Аннотация
PURPOSE: Outcomes after adjuvant radiotherapy for cutaneous melanoma with perineural invasion (PNI).
METHODS: Seven patients (5 cutaneous, 2 recurrent nerve lesions) received radiotherapy.
RESULTS: At a median 4.5 years: Two patients did not recur; no local failures occurred. Three patients who omitted nodal irradiation developed regional failures (2 out-of-field, 1 in-field). Three patients developed distant metastases. Four died with disease (median, 3.6 years); 1 died from intercurrent disease (13.0 years). Two are alive without disease (6.8 and 11.6 years). No patient experienced grade ≥3 toxicity.
CONCLUSIONS: Postoperative radiotherapy can reduce local recurrences; primary radiotherapy for unresectable disease is recommended.
METHODS: Seven patients (5 cutaneous, 2 recurrent nerve lesions) received radiotherapy.
RESULTS: At a median 4.5 years: Two patients did not recur; no local failures occurred. Three patients who omitted nodal irradiation developed regional failures (2 out-of-field, 1 in-field). Three patients developed distant metastases. Four died with disease (median, 3.6 years); 1 died from intercurrent disease (13.0 years). Two are alive without disease (6.8 and 11.6 years). No patient experienced grade ≥3 toxicity.
CONCLUSIONS: Postoperative radiotherapy can reduce local recurrences; primary radiotherapy for unresectable disease is recommended.