[The effect of humoral factors of hypothalamic nonapeptidergic centers on histo- and organotypical potentialites of digestive glands of various developmental origin under conditions of in vivo culture by F.M. Lazarenko's method].

The aim of the present investigation was to study the role of hypothalamic nonapeptides in the regulation of proliferation, growth and cell differentiation processes in glandular epithelia of different developmental origin (parotid gland and pancreas of albino rats) under conditions of in vivo organotypical culture by F.M. Lazarenko's method. Histoautoradiography, light and electron microscopy methods were used. Hypothalamic nonapeptides were shown to cause the dedifferentation of glandular epithelium, intensification of DNA-synthetic activity of epithelial cells, fibroblasts, macrophages, to optimize secondary differentation in the newly formed glandular structures, to stimulate the vasculogenesis and fibrillogenesis in an undifferentiated connective tissue. The humoral factors studied provide the conditions for the realization of histo- and organotypical potentialities by the epithelia of parotid gland and pancreas without interfering with their genetic determination. Adaptogenic role of neurohormones in the control of cell and tissue homeostasis of the cultured organ fragments is discussed.