European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2025
Tumor deposits in gastric cancer cannot be regarded as metastatic lymph nodes: A single-center retrospective study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Xu Ran, Li Yang, Zhao Haiyuan, Wang Zhengguang, Chen Ke, Zhao Jun, Zhang Yisheng
Аннотация
BACKGROUND: In gastric cancer (GC), the significance of the number of tumor deposits (TDs) in prognostic evaluation remains a subject of debate. This study aims to investigate whether TDs can be equated to regional metastatic lymph nodes, potentially improving the accuracy of prognostic assessments in patients with TDs.
METHODS: A retrospective analysis of clinicopathologic and follow-up data from patients who underwent radical gastrectomy at Yijishan Hospital of Wannan Medical College over a decade, from January 2012 to December 2021, was conducted. Patients were classified into TDs-negative and TDs-positive groups on the basis of the detection of TDs in their postoperative pathology reports.
RESULTS: The study included 4972 patients, with 575 (11.56 %) identified as having TDs. Among these, 524 TDs-positive patients were matched at a 1:1 ratio with 524 TDs-negative patients. Under the original TNM staging system, the chi-square (χ2) value was 58.234, with a C-index of 0.593. When TDs were classified as regional metastatic lymph nodes, the χ2 value for the modified TNM staging system rose to 72.269, with an improved C-index of 0.609. Nevertheless, the prognosis within the TDs-positive subgroups IIIa, IIIb, and IIIc was still significantly worse than those in the TDs-negative subgroup, even when TDs were reclassified for staging purposes (P < 0.001).
CONCLUSION: Although treating TDs as regional metastatic lymph nodes can increase the accuracy of disease staging in GC patients, it does not necessarily convey the true prognostic value of TDs.
METHODS: A retrospective analysis of clinicopathologic and follow-up data from patients who underwent radical gastrectomy at Yijishan Hospital of Wannan Medical College over a decade, from January 2012 to December 2021, was conducted. Patients were classified into TDs-negative and TDs-positive groups on the basis of the detection of TDs in their postoperative pathology reports.
RESULTS: The study included 4972 patients, with 575 (11.56 %) identified as having TDs. Among these, 524 TDs-positive patients were matched at a 1:1 ratio with 524 TDs-negative patients. Under the original TNM staging system, the chi-square (χ2) value was 58.234, with a C-index of 0.593. When TDs were classified as regional metastatic lymph nodes, the χ2 value for the modified TNM staging system rose to 72.269, with an improved C-index of 0.609. Nevertheless, the prognosis within the TDs-positive subgroups IIIa, IIIb, and IIIc was still significantly worse than those in the TDs-negative subgroup, even when TDs were reclassified for staging purposes (P < 0.001).
CONCLUSION: Although treating TDs as regional metastatic lymph nodes can increase the accuracy of disease staging in GC patients, it does not necessarily convey the true prognostic value of TDs.