Exosomes in Cutaneous Wound Healing and Facial Skin Regeneration: Clinical and Translational Perspectives.

Exosomes-small extracellular vesicles containing protein, lipid, and nucleic-acid cargo-modulate key pathways involved in inflammation, angiogenesis, and extracellular matrix remodeling. This narrative review synthesizes current pre-clinical and clinical evidence supporting exosome-based interventions in cutaneous wound healing and facial skin regeneration, with attention to delivery strategies, translational limitations, and regulatory considerations relevant to facial plastic and reconstructive surgery. Across multiple in vivo models, exosome-based therapies have been associated with accelerated wound closure, enhanced neovascularization, and more organized collagen architecture, with attenuation of excessive fibrotic remodeling in later phases of healing.