[Acute lymphoblastic leukemia complicated with tumor lysis syndrome--four cases report].

OBJECTIVE

To report four acute lymphoblastic leukemia(ALL) patients who developed tumor lysis syndrome(TLS) after initial chemotherapy.

METHODS

The clinical features and blood biochemical changes of four patients with TLS were analysed.

RESULTS

TLS was characterized by hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia. Three cases had renal dysfunction and the other died of acute renal failure. After allopurinol therapy and alkalinization of urine, the blood biochemical parameter became normalization in all the three cases.

CONCLUSIONS

TLS can be effectively controlled by early recognition and administration of allopurinol therapy and alkalinization of urine.