[Intratumoral administration of 5-fluorouracil and bleomycin in inoperable cancer of the cardioesophageal region].

The methods and results of combined therapy (drugs+radiation+intratumoral injection of 5-fluorouracil and (chemoimmunotherapy+intratumoral injection of bleomycin) were compared with the standard procedure (chemotherapy+radiation) for treating inoperable cancer in the cardioesophageal region. The study group included 47 patients aged 32-79. Tumors were inoperable due to considerable expansion in 32 and remote metastases in 15 patients. The single dose of 5-fluorouracil injected into tumor via a fibroendoscope at the start of chemoradiation treatment ranged 750-1,000 mg (course dose of the drug-2.75-4.25 g, total focal dose of radiation -24-36 Gy). The single intratumoral dose of bleomycin injected prior to total polychemotherapy (vinblastine, ftorafur, cyclophosphamide) was 10-15 mg. In the control group receiving standard combined therapy, the total focal dose was 60-62 Gy and course dose of 5-fluorouracil -5-7 g. Objective improvement was observed in 63.6% matched by a mean survival time of 14.6 months after combined therapy given in conjunction with supporting chemoimmunotherapy. This showed an improvement on the results of standard combination therapy which were 58.3% and 9.3 months, respectively.