Journal of the American Academy of Dermatology · 1999
Risk of cutaneous malignant melanoma in patients with nonfamilial atypical nevi from a pigmented lesions clinic.
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Snels D G, Hille E T, Gruis N A, Bergman W
Аннотация
BACKGROUND: Atypical nevi (AN) are regarded as a major risk factor for occurrence of malignant melanoma. Few studies report an increase in relative risk for melanoma in patients with nonfamilial AN.
OBJECTIVE: We measured the risk of melanoma in 195 patients with nonfamilial AN.
METHODS: In a retrospective follow-up study the number of newly diagnosed melanomas during follow-up were inventoried. Included patients were invited for skin screening and nevus count.
RESULTS: On the basis of our calculations, the relative risk for invasive melanoma in patients with nonfamilial AN, including those patients with a history of melanoma, is 41. For individuals with AN without a previously diagnosed melanoma, the relative risk was 37. Multivariate analysis did not reveal a specific risk factor for the occurrence of melanoma (including number of AN) because of small numbers. Invasive melanomas occurred in persons having 1, 5, 12, and 172 AN, respectively.
CONCLUSION: An increased risk for invasive cutaneous malignant melanoma in patients with nonfamilial AN was established.
OBJECTIVE: We measured the risk of melanoma in 195 patients with nonfamilial AN.
METHODS: In a retrospective follow-up study the number of newly diagnosed melanomas during follow-up were inventoried. Included patients were invited for skin screening and nevus count.
RESULTS: On the basis of our calculations, the relative risk for invasive melanoma in patients with nonfamilial AN, including those patients with a history of melanoma, is 41. For individuals with AN without a previously diagnosed melanoma, the relative risk was 37. Multivariate analysis did not reveal a specific risk factor for the occurrence of melanoma (including number of AN) because of small numbers. Invasive melanomas occurred in persons having 1, 5, 12, and 172 AN, respectively.
CONCLUSION: An increased risk for invasive cutaneous malignant melanoma in patients with nonfamilial AN was established.
Предметные рубрики MeSH
AdolescentAdultAge FactorsAgedChi-Square DistributionConfidence IntervalsFemaleFollow-Up StudiesHumansLogistic ModelsMaleMass ScreeningMelanomaMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm Recurrence, LocalNevus, PigmentedOdds RatioRetrospective StudiesRisk FactorsSex FactorsSkin NeoplasmsSkin Pigmentation