Acta ophthalmologica Scandinavica · 1999
The role of UV-radiation in the development of conjunctival malignant melanoma.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
El-Shabrawi Y, Radner H, Muellner K, Langmann G, Hoefler G
Аннотация
PURPOSE: To investigate the possible role of UV-radiation in the development of conjunctival malignant melanoma. N-ras mutations are frequently found in cutaneous melanomas of sun-exposed body areas. UV-radiation is thought to induce mutations in the N-ras gene, that convert these genes into active oncogenes. The presence of N-ras mutations has been considered an indicator for UV-exposure in the development of melanomas on sun-exposed body sides.
METHODS: We analyzed six paraffin-embedded conjunctival melanomas for mutations of the N-ras gene. Codons 12, 13 and 61 were amplified using polymerase chain reaction and sequenced.
RESULTS: We could not detect point mutations of the N-ras gene in our samples.
CONCLUSION: Since we could not find deviations from the wild type sequence in the N-ras gene, our study does not support UV-exposure as being causative in the development of conjunctival melanoma.
METHODS: We analyzed six paraffin-embedded conjunctival melanomas for mutations of the N-ras gene. Codons 12, 13 and 61 were amplified using polymerase chain reaction and sequenced.
RESULTS: We could not detect point mutations of the N-ras gene in our samples.
CONCLUSION: Since we could not find deviations from the wild type sequence in the N-ras gene, our study does not support UV-exposure as being causative in the development of conjunctival melanoma.