Anticancer research · 2014
Cell-adhesion molecule expression and the proliferation of malignant mesothelioma: a post-mortem examination.
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Kuribayashi Kozo, Hirano Hiroshi, Nakasho Keiji, Ohyama Hideki, Yamanegi Koji, Tabata Chiharu, Fukuoka Kazuya, Fujimori Yoshihiro, Nakano Takashi
Аннотация
AIM: In order to determine if metastatic malignant mesothelioma cells are more aggressive than primary malignant mesothelioma cells, an analysis of the expression of the adhesion molecules E-cadherin and β-catenin, concomitant with an assessment of the proliferative activity at primary and metastatic sites, was conducted in post-mortem samples.
MATERIALS AND METHODS: E-cadherin or β-catenin expression was graded according to the percentage of positively-stained tumor cells. The proliferative activity was quantified by the Ki-67 labeling index.
RESULTS: Histologically, the majority of metastatic tumors matched the primary tumor. In the epithelioid component of primary tumors, E-cadherin and β-catenin expression ranged from 1+ to 4+.
CONCLUSION: Malignant mesothelioma cells acquire a higher proliferative potential after metastasis, without any significant changes in their histology, although metastasis produces no definite trend on the expression of E-cadherin or β-catenin.
MATERIALS AND METHODS: E-cadherin or β-catenin expression was graded according to the percentage of positively-stained tumor cells. The proliferative activity was quantified by the Ki-67 labeling index.
RESULTS: Histologically, the majority of metastatic tumors matched the primary tumor. In the epithelioid component of primary tumors, E-cadherin and β-catenin expression ranged from 1+ to 4+.
CONCLUSION: Malignant mesothelioma cells acquire a higher proliferative potential after metastasis, without any significant changes in their histology, although metastasis produces no definite trend on the expression of E-cadherin or β-catenin.