Acta obstetricia et gynecologica Scandinavica · 1997
Immunohistochemical localization of nitric oxide synthase in human fetal membranes.
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Marinoni E, Di Iorio R, Scucchi L, Cosmi E V
Аннотация
SUBJECT: It has been demonstrated that L-arginine-nitric oxide (NO) system is present in the myometrium during pregnancy where it can regulate uterine contractility.
MATERIAL AND METHOD: We have studied by immunohistochemistry the localization of constitutive endothelial nitric oxide synthase (ecNOS) and brain nitric oxide synthase (bNOS) in human fetal membranes in term non laboring women.
RESULTS: The amniotic epithelium and the trophoblast of chorion layer stained intensively for bNOS, while for ecNOS the immunoreactivity was weak and restricted to trophoblast cells.
CONCLUSION: These findings are suggestive for NO production by the fetal membranes in term pregnancy.
MATERIAL AND METHOD: We have studied by immunohistochemistry the localization of constitutive endothelial nitric oxide synthase (ecNOS) and brain nitric oxide synthase (bNOS) in human fetal membranes in term non laboring women.
RESULTS: The amniotic epithelium and the trophoblast of chorion layer stained intensively for bNOS, while for ecNOS the immunoreactivity was weak and restricted to trophoblast cells.
CONCLUSION: These findings are suggestive for NO production by the fetal membranes in term pregnancy.