British journal of obstetrics and gynaecology · 1997
The role of endogenous nitric oxide synthesis in contractility of term or preterm human myometrium.
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Jones G D, Poston L
Аннотация
OBJECTIVE: To assess in vitro the role of endogenous myometrial nitric oxide synthesis on human myometrial contraction.
DESIGN: Strips of myometrium were mounted in a standard organ bath for assessment of isometric contraction and the response to modulators of nitric oxide synthesis determined.
SETTING: A teaching hospital research laboratory.
SAMPLE: Women undergoing elective nonlabour caesarean section under regional anaesthesia: 54 at term and seven preterm.
RESULTS: Neither addition of L-arginine, the substrate for nitric oxide synthase, nor of an inhibitor of nitric oxide synthase led to any specific change in spontaneous myometrial contraction.
CONCLUSION: Endogenous nitric oxide production does not play an important role in the control of human term of preterm nonlabouring uterine smooth muscle contractility.
DESIGN: Strips of myometrium were mounted in a standard organ bath for assessment of isometric contraction and the response to modulators of nitric oxide synthesis determined.
SETTING: A teaching hospital research laboratory.
SAMPLE: Women undergoing elective nonlabour caesarean section under regional anaesthesia: 54 at term and seven preterm.
RESULTS: Neither addition of L-arginine, the substrate for nitric oxide synthase, nor of an inhibitor of nitric oxide synthase led to any specific change in spontaneous myometrial contraction.
CONCLUSION: Endogenous nitric oxide production does not play an important role in the control of human term of preterm nonlabouring uterine smooth muscle contractility.