Biomarkers in medicine · 2022
Biomarker evaluation for prognostic stratification of patients with COVID-19: the added value of quantitative chest CT.
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Ferreira Roberto M, de Oliveira Gabriel Ss, da Rocha João Rf, Mc Ribeiro Felipe de, Stern João J, S Costa Rangel de, Lemgruber Ricardo N, Ramalho Júlia Fp, de Almeida Alexandre Cp, Sampaio Pedro Pn, Filho João Mansur, Lima Ricardo Ac
Аннотация
Aim: Pulmonary disease burden and biomarkers are possible predictors of outcomes in patients with COVID-19 and provide complementary information. In this study, the prognostic value of adding quantitative chest computed tomography (CT) to a multiple biomarker approach was evaluated among 148 hospitalized patients with confirmed COVID-19. Materials & methods: Patients admitted between March and July 2020 who were submitted to chest CT and biomarker measurement (troponin I, D-dimer and C-reactive protein) were retrospectively analyzed. Biomarker and tomographic data were compared and associated with death and intensive care unit admission. Results: The number of elevated biomarkers was significantly associated with greater opacification percentages, lower lung volumes and higher death and intensive care unit admission rates. Total lung volume <3.0 l provided further stratification for mortality when combined with biomarker evaluation. Conclusion: Adding automated CT data to a multiple biomarker approach may provide a simple strategy for enhancing risk stratification of patients with COVID-19.