Dermatology (Basel, Switzerland) · 1996
Expression of autocrine motility factor receptor in cutaneous malignant melanoma.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Nagai Y, Ishikawa O, Miyachi Y, Watanabe H
Аннотация
BACKGROUND: The autocrine motility factor receptor (AMFR), a specific receptor for AME, is considered to be related to the metastatic potential of tumor cells.
OBJECTIVE: We investigated whether AMFR is expressed on cutaneous malignant melanoma cells and has any relationship to clinical stage and metastatic ability.
METHODS: We performed an immunohistochemical study on 20 cases of cutaneous malignant melanoma using anti-AMFR antibody. AMFR was expressed in 9 cases (45%), and its expression had a tendency to correlate with the clinical stage and the presence of lymph node metastasis.
CONCLUSIONS: The expression of AMFR may have a possible association with the metastatic potential of malignant melanoma.
OBJECTIVE: We investigated whether AMFR is expressed on cutaneous malignant melanoma cells and has any relationship to clinical stage and metastatic ability.
METHODS: We performed an immunohistochemical study on 20 cases of cutaneous malignant melanoma using anti-AMFR antibody. AMFR was expressed in 9 cases (45%), and its expression had a tendency to correlate with the clinical stage and the presence of lymph node metastasis.
CONCLUSIONS: The expression of AMFR may have a possible association with the metastatic potential of malignant melanoma.
Предметные рубрики MeSH
Biopsy, NeedleDiagnosis, DifferentialDysplastic Nevus SyndromeHumansImmunohistochemistryLymphatic MetastasisMelanomaNeoplasm MetastasisNeoplasm StagingReceptors, Autocrine Motility FactorReceptors, CytokineReference ValuesRetrospective StudiesSensitivity and SpecificitySkin NeoplasmsUbiquitin-Protein Ligases