Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma.
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Krämer Pauline, Talhouk Aline, Brett Mary Anne, Chiu Derek S, Cairns Evan S, Scheunhage Daniëlla A, Hammond Rory F L, Farnell David, Nazeran Tayyebeh M, Grube Marcel, Xia Zhouchunyang, Senz Janine, Leung Samuel, Feil Lukas, Pasternak Jana, Dixon Katherine, Hartkopf Andreas, Krämer Bernhard, Brucker Sara, Heitz Florian, du Bois Andreas, Harter Philipp, Kommoss Felix K F, Sinn Hans-Peter, Heublein Sabine, Kommoss Friedrich, Vollert Hans-Walter, Manchanda Ranjit, de Kroon Cornelis D, Nijman Hans W, de Bruyn Marco, Thompson Emily F, Bashashati Ali, McAlpine Jessica N, Singh Naveena, Tinker Anna V, Staebler Annette, Bosse Tjalling, Kommoss Stefan, Köbel Martin, Anglesio Michael S
Аннотация
EXPERIMENTAL DESIGN: IHC and mutation biomarkers were used to segregate 511 ENOC tumors into four EC-inspired molecular subtypes: low-risk POLE mutant (POLEmut), moderate-risk mismatch repair deficient (MMRd), high-risk p53 abnormal (p53abn), and moderate-risk with no specific molecular profile (NSMP). Survival analysis with established clinicopathologic and subtype-specific features was performed.
RESULTS: A total of 3.5% of cases were POLEmut, 13.7% MMRd, 9.6% p53abn, and 73.2% NSMP, each showing distinct outcomes (P < 0.001) and survival similar to observations in EC. Median OS was 18.1 years in NSMP, 12.3 years in MMRd, 4.7 years in p53abn, and not reached for POLEmut cases. Subtypes were independent of stage, grade, and residual disease in multivariate analysis.
CONCLUSIONS: EC-inspired molecular classification provides independent prognostic information in ENOC. Our findings support investigating molecular subtype-specific management recommendations for patients with ENOC; for example, subtypes may provide guidance when fertility-sparing treatment is desired. Similarities between ENOC and EC suggest that patients with ENOC may benefit from management strategies applied to EC and the opportunity to study those in umbrella trials.