Internal medicine (Tokyo, Japan) · 2018
Nivolumab Induces Sustained Liver Injury in a Patient with Malignant Melanoma.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Matsubara Tokuhiro, Nishida Tsutomu, Higaki Yu, Tomita Ryo, Shimakoshi Hiromi, Shimoda Akiyoshi, Osugi Naoto, Sugimoto Aya, Takahashi Kei, Nakamatsu Dai, Mukai Kaori, Yamamoto Masashi, Fukui Koji, Adachi Shiro, Inada Masami
Аннотация
A 42-year-old man was diagnosed with cStage IIIb malignant melanoma and underwent resection. After interferon-beta therapy, 18-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG PET/CT) showed multiple lung metastases, and he received nivolumab (2 mg/kg) every 3 weeks, resulting in a total of 17 cycles. After treatment, 18F-FDG PET/CT showed a significant decrease in the size of the metastases, but he had a Grade 4 alanine aminotransferase (ALT) elevation. Liver histology revealed drug-induced liver damage. Therefore, we performed steroid half-pulse therapy followed by oral methylprednisolone, but his ALT level did not completely recover to the normal range even after five months. We herein report a case with specific, sustained liver injury induced by nivolumab as an immune-related adverse events.