Long-term outcomes among 2-year survivors of autologous hematopoietic cell transplantation for Hodgkin and diffuse large b-cell lymphoma.
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Myers Regina M, Hill Brian T, Shaw Bronwen E, Kim Soyoung, Millard Heather R, Battiwalla Minoo, Majhail Navneet S, Buchbinder David, Lazarus Hillard M, Savani Bipin N, Flowers Mary E D, D'Souza Anita, Ehrhardt Matthew J, Langston Amelia, Yared Jean A, Hayashi Robert J, Daly Andrew, Olsson Richard F, Inamoto Yoshihiro, Malone Adriana K, DeFilipp Zachariah, Margossian Steven P, Warwick Anne B, Jaglowski Samantha, Beitinjaneh Amer, Fung Henry, Kasow Kimberly A, Marks David I, Reynolds Jana, Stockerl-Goldstein Keith, Wirk Baldeep, Wood William A, Hamadani Mehdi, Satwani Prakash
Аннотация
METHODS: This study analyzed survival, nonrelapse mortality, late effects, and subsequent malignant neoplasms (SMNs) in 1617 patients who survived progression-free for ≥2 years after auto-HCT for cHL or DLBCL between 1990 and 2008. The median age at auto-HCT was 40 years; the median follow-up was 10.6 years.
RESULTS: The 5-year overall survival rate was 90% (95% confidence interval [CI], 87%-92%) for patients with cHL and 89% (95% CI, 87%-91%) for patients with DLBCL. The risk of late mortality in comparison with the general population was 9.6-fold higher for patients with cHL (standardized mortality ratio [SMR], 9.6) and 3.4-fold higher for patients with DLBCL (SMR, 3.4). Relapse accounted for 44% of late deaths. At least 1 late effect was reported for 9% of the patients. A total of 105 SMNs were confirmed: 44 in the cHL group and 61 in the DLBCL group. According to a multivariate analysis, older age, male sex, a Karnofsky score < 90, total body irradiation (TBI) exposure, and a higher number of lines of chemotherapy before auto-HCT were risk factors for overall mortality in cHL. Risk factors in DLBCL were older age and TBI exposure. A subanalysis of 798 adolescent and young adult patients mirrored the outcomes of the overall study population.
CONCLUSIONS: Despite generally favorable outcomes, 2-year survivors of auto-HCT for cHL or DLBCL have an excess late-mortality risk in comparison with the general population and experience an assortment of late complications. Cancer 2018;124:816-25. © 2017 American Cancer Society.