Cell death & disease · 2017
The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zalfa Francesca, Panasiti Vincenzo, Carotti Simone, Zingariello Maria, Perrone Giuseppe, Sancillo Laura, Pacini Laura, Luciani Flavie, Roberti Vincenzo, D'Amico Silvia, Coppola Rosa, Abate Simona Osella, Rana Rosa Alba, De Luca Anastasia, Fiers Mark, Melocchi Valentina, Bianchi Fabrizio, Farace Maria Giulia, Achsel Tilmann, Marine Jean-Christophe, Morini Sergio, Bagni Claudia
Аннотация
The fragile X mental retardation protein (FMRP) is lacking or mutated in patients with the fragile X syndrome (FXS), the most frequent form of inherited intellectual disability. FMRP affects metastasis formation in a mouse model for breast cancer. Here we show that FMRP is overexpressed in human melanoma with high Breslow thickness and high Clark level. Furthermore, meta-analysis of the TCGA melanoma data revealed that high levels of FMRP expression correlate significantly with metastatic tumor tissues, risk of relapsing and disease-free survival. Reduction of FMRP in metastatic melanoma cell lines impinges on cell migration, invasion and adhesion. Next-generation sequencing in human melanoma cells revealed that FMRP regulates a large number of mRNAs involved in relevant processes of melanoma progression. Our findings suggest an association between FMRP levels and the invasive phenotype in melanoma and might open new avenues towards the discovery of novel therapeutic targets.