[A Case of Signet Ring Cell Pancreatic Carcinoma Showing Long-Term Survival with Chemotherapy].

A man in his 60s was referred to us because of weight loss and epigastric distress. Computed tomography revealed a 100 mm tumor in the pancreatic body and tail, which directly invaded the celiac, common hepatic, splenic, and left gastric arteries. Metastatic lymph nodes and peritoneal dissemination were also observed. The tumor had invaded the gastric wall, and an endoscopic biopsy of the stomach tumor was performed. Histologically, the tumor was diagnosed as a signet ring cell carcinoma with a poorly differentiated adenocarcinoma component. The patient was diagnosed with advanced pancreatic cancer(cT4N1bM1, Stage Ⅳ). Radical excision was not possible; therefore, chemotherapy was planned. He initially received 6 cycles of mFOLFIRINOX, followed by 6 cycles of GnP. Post-therapeutic imaging showed a reduction in the size of the primary pancreatic tumor, and the levels of tumor markers had markedly decreased. However, the tumor progressed again, and the patient died 14 months later. Signet ring cell carcinoma is a rare type of pancreatic cancer, with few reported cases worldwide. Here, we report a case of signet ring cell carcinoma with long-term survival in a patient with pancreatic cancer.