Journal of the American Academy of Dermatology · 2026
Low-dose long-term capecitabine for refractory field cancerization: A retrospective cohort study.
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Neff Haley, Mortelliti Caroline, Solomon Brenda, Karn Emily, Stump Madeliene, Ran Nina A, Silk Ann W, Ruiz Emily S
Аннотация
BACKGROUND: Topical-refractory cutaneous field cancerization is challenging to manage and distressing to patients.
OBJECTIVE: Evaluate the efficacy, toxicity, and patient satisfaction of long-term, low-dose capecitabine for field cancerization.
METHODS: A retrospective cohort and survey study was performed at a single institution of patients treated with capecitabine for cutaneous field cancerization. Wilcoxon matched-pairs signed-rank test was used to compare annual keratinocyte carcinoma surgeries pre- and post-treatment at years 1, 2, and 3.
RESULTS: Twenty patients were treated over 20.8 months (range 0.8-57.5) including 8.0 months (0-33.1) of intervening treatment holidays. Mean keratinocyte carcinoma surgeries decreased in all years of treatment compared to the year before treatment (1-year (n = 18): 3.89 precapecitabine to 2.94, 24% reduction, P = .29; 2-year (n = 11): 3.46 precapecitabine to 0.93, 73% reduction, P = .02; 3-year (n = 5): 3.00 precapecitabine to 2.20, 27% reduction, P > .99). Two patients (10%) discontinued therapy due to toxicity. Of 17 patients offered the survey, 12 responded (response rate 70.6%). A majority (75.0%) felt capecitabine improved their skin lesions at least moderately and 83.3% preferred capecitabine to alternative treatments.
LIMITATIONS: Retrospective design, small sample size.
CONCLUSION: Capecitabine reduces incident keratinocyte carcinomas and is well-tolerated long-term.
OBJECTIVE: Evaluate the efficacy, toxicity, and patient satisfaction of long-term, low-dose capecitabine for field cancerization.
METHODS: A retrospective cohort and survey study was performed at a single institution of patients treated with capecitabine for cutaneous field cancerization. Wilcoxon matched-pairs signed-rank test was used to compare annual keratinocyte carcinoma surgeries pre- and post-treatment at years 1, 2, and 3.
RESULTS: Twenty patients were treated over 20.8 months (range 0.8-57.5) including 8.0 months (0-33.1) of intervening treatment holidays. Mean keratinocyte carcinoma surgeries decreased in all years of treatment compared to the year before treatment (1-year (n = 18): 3.89 precapecitabine to 2.94, 24% reduction, P = .29; 2-year (n = 11): 3.46 precapecitabine to 0.93, 73% reduction, P = .02; 3-year (n = 5): 3.00 precapecitabine to 2.20, 27% reduction, P > .99). Two patients (10%) discontinued therapy due to toxicity. Of 17 patients offered the survey, 12 responded (response rate 70.6%). A majority (75.0%) felt capecitabine improved their skin lesions at least moderately and 83.3% preferred capecitabine to alternative treatments.
LIMITATIONS: Retrospective design, small sample size.
CONCLUSION: Capecitabine reduces incident keratinocyte carcinomas and is well-tolerated long-term.
Предметные рубрики MeSH
HumansCapecitabineRetrospective StudiesFemaleSkin NeoplasmsAntimetabolites, AntineoplasticAgedMaleMiddle AgedAged, 80 and overBasal Cell CarcinomaCarcinoma, Squamous CellCohort StudiesPatient SatisfactionTreatment OutcomeDrug Administration ScheduleTime FactorsNon-Melanoma Skin NeoplasmsCutaneous Squamous Cell Carcinoma