Osteosarcoma of the Jaws in Latin America: A Retrospective Multicenter Series of 119 Cases.
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Ошибки и ограничения
История · было → стало
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Drumond Victor Zanetti, de Arruda José Alcides Almeida, Villaroel-Dorrego Mariana, Dos Reis Leonardo Amaral, Sampaio Gerhilde Callou, Schuch Lauren Frenzel, Menna-Barreto Carolina Louzada, Martins Manoela Domingues, Goulart Paula Celeghini, Souza Guilherme Gomes, de Souza Fabrício Tinôco Alvim, Silva Warley Oliveira, Cordero-Torres Karina, Morales-Espinosa Rolando, Panico René, Gilligan Gerardo, Garola Federico, Cerullo Carlos Marcelo, Leonardi Nicolás, Giménez Javier, Flück Verónica, Castrillo Ángeles, Leguina Laura, Peña-Vega Claudia Patricia, Rodríguez-Mora Juan Pablo, Mezzomo-Faccin Kallana, de Albuquerque-Junior Ricardo Luiz Cavalcanti, Gondak Rogério, Israel Mônica Simões, Alves Pollianna Muniz, Gomes Amanda Claudino, Nonaka Cassiano Francisco Weege, Ribeiro Michel Campos, de Mendonça Elismauro Francisco, Moreira Victor Hugo Lopes de Oliveira, Arantes Diego Antônio Costa, Cavalcante Israel Leal, Turatti Eveline, Cavalcante Roberta Barroso, Tacchi Giovanna, Gomes Ana Paula Neutzling, Bubolz Karen Müller, Etges Adriana, Umpiérrez María Natalia González, Cueto Natalia Fernanda Tancredi, Beovide-Cortegoso Aurita Verónica, Bologna-Molina Ronell, Aranda-Romo Saray, Tejeda-Nava Francisco Javier, Abreu Lucas Guimarães, de Andrade Bruno Augusto Benevenuto, Mesquita Ricardo Alves
Аннотация
METHODS: This multicenter case series involved 22 institutions from Brazil, Chile, Argentina, Colombia, Venezuela, Uruguay, and Mexico. Demographic, clinical, radiographic, histopathological, treatment, and survival data were analyzed using descriptive and inferential statistical methods. Survival outcomes were assessed using Kaplan-Meier analysis and Cox regression models.
RESULTS: A total of 119 OSJ cases were included. The median age was 33 years, with a female predominance (58%), and the mandible was the most commonly affected site (68.9%). A mixed radiographic appearance predominated and was frequently accompanied by cortical perforation and a sunburst periosteal reaction. Histologically, the osteoblastic subtype accounted for 63.5% of cases. Surgical resection was the main treatment modality (71.2%). Increasing age (p = 0.034) and multimodal or nonsurgical management (p = 0.023) were independently associated with poorer survival. The estimated overall survival rates were 67.5% at 12 months and 37.5% at 60 months.
CONCLUSION: Data corroborate previous literature and demonstrate that OSJ in Latin America predominantly affects adults and exhibits aggressive patterns. Surgical management remains central to improving survival whenever it is technically feasible.