Annals of Saudi medicine · 2026
Community-acquired Escherichia coli pneumonia: clinical, radiological, laboratory, and prognostic characteristics in a retrospective single-center study.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Kücük Salih, Mutlu Sükran, Dogan Coskun, Soydan Sevda
Аннотация
BACKGROUND: Community-acquired pneumonia (CAP) caused by Escherichia coli (E. coli) is uncommon, and its clinical features and prognosis remain insufficiently characterized.
OBJECTIVES: To compare the clinical, laboratory, radiological, and prognostic characteristics of community-acquired E. coli pneumonia (CAECP) with CAP caused by other pathogens.
DESIGN: Single-center retrospective observational cohort study.
SETTINGS: Department of Pulmonology, Kocaeli City Hospital, İzmit, Kocaeli, Türkiye from April 2023 to March 2025.
PATIENTS AND METHODS: Adult patients hospitalized with CAP and positive sputum cultures were reviewed. Hospital-acquired and ventilator-associated pneumonias were excluded. Patients were classified as CAECP or Other-CAP. Demographic, clinical, laboratory, radiological, CURB-65, Pneumonia Severity Index (PSI), and outcome data were compared. A targeted multivariable logistic regression model adjusted for age and malignancy evaluated 90-day mortality.
MAIN OUTCOME MEASURES: In-hospital mortality, 90-day mortality, intensive care unit admission, and hospital length of stay.
SAMPLE SIZE: Sixty-eight patients (37 CAECP, 31 Other-CAP).
RESULTS: Median age (69 [interquartile range, IQR 50.7-71] vs 67 [56-70] years; P=.805), sex distribution (P=.452), comorbidity burden (P=.094), body temperature (P=.970), heart rate (P=.592), C-reactive protein (P=.731), procalcitonin (P=.749), multilobar involvement (P=.246), and air bronchogram (P=.938) were comparable between groups. Mean CURB-65 (1.73±0.90 vs 1.45±0.99; P=.253) and PSI (108.6±40.6 vs 95.4±27.6; P=.143) were also similar. Hospital stay was significantly longer in CAECP (15.7±15.5 vs 9.6±7.0) days; P=.047). In-hospital mortality was numerically higher (14% vs 0; P=.058), while 90-day mortality was significantly higher (49% vs 16%; P=.005). After adjustment for age and malignancy, CAECP remained independently associated with 90-day mortality (aOR, 7.41; 95% CI, 1.85-29.71; P=.005).
CONCLUSION: CAECP resembles other CAP etiologies at presentation, but is associated with longer hospitalization and markedly higher 90-day mortality despite similar baseline severity scores.
LIMITATIONS: Single-center retrospective design, small sample size, and limited number of mortality events.
OBJECTIVES: To compare the clinical, laboratory, radiological, and prognostic characteristics of community-acquired E. coli pneumonia (CAECP) with CAP caused by other pathogens.
DESIGN: Single-center retrospective observational cohort study.
SETTINGS: Department of Pulmonology, Kocaeli City Hospital, İzmit, Kocaeli, Türkiye from April 2023 to March 2025.
PATIENTS AND METHODS: Adult patients hospitalized with CAP and positive sputum cultures were reviewed. Hospital-acquired and ventilator-associated pneumonias were excluded. Patients were classified as CAECP or Other-CAP. Demographic, clinical, laboratory, radiological, CURB-65, Pneumonia Severity Index (PSI), and outcome data were compared. A targeted multivariable logistic regression model adjusted for age and malignancy evaluated 90-day mortality.
MAIN OUTCOME MEASURES: In-hospital mortality, 90-day mortality, intensive care unit admission, and hospital length of stay.
SAMPLE SIZE: Sixty-eight patients (37 CAECP, 31 Other-CAP).
RESULTS: Median age (69 [interquartile range, IQR 50.7-71] vs 67 [56-70] years; P=.805), sex distribution (P=.452), comorbidity burden (P=.094), body temperature (P=.970), heart rate (P=.592), C-reactive protein (P=.731), procalcitonin (P=.749), multilobar involvement (P=.246), and air bronchogram (P=.938) were comparable between groups. Mean CURB-65 (1.73±0.90 vs 1.45±0.99; P=.253) and PSI (108.6±40.6 vs 95.4±27.6; P=.143) were also similar. Hospital stay was significantly longer in CAECP (15.7±15.5 vs 9.6±7.0) days; P=.047). In-hospital mortality was numerically higher (14% vs 0; P=.058), while 90-day mortality was significantly higher (49% vs 16%; P=.005). After adjustment for age and malignancy, CAECP remained independently associated with 90-day mortality (aOR, 7.41; 95% CI, 1.85-29.71; P=.005).
CONCLUSION: CAECP resembles other CAP etiologies at presentation, but is associated with longer hospitalization and markedly higher 90-day mortality despite similar baseline severity scores.
LIMITATIONS: Single-center retrospective design, small sample size, and limited number of mortality events.