Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium.
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Džinalija Nadža, van den Heuvel Odile A, Simpson H Blair, Ivanov Iliyan, Araújo Ana, Balachander Srinivas, Beucke Jan, Brandeis Daniel, Brem Silvia, Bruin Willem, Buitelaar Jan, Castelo-Branco Miguel, Choi Sunah, Eng Goi Khia, Fitzsimmons Sophie M D D, Fortea Lydia, Fullana Miquel A, Grützmann Rosa, Hansen Bjarne, Huijser Chaim, de Joode Niels T, Kathmann Norbert, Kaufmann Christian, Kim Minah, Koch Kathrin, Kwon Jun Soo, Lim Jie Xin, Martinez-Zalacain Ignacio, Menchon Jose M, van de Mortel Laurens A, Narayanaswamy Janardhanan C, Ousdal Olga Therese, Postma Tjardo S, Rodriguez-Manrique Daniela, van Rooij Daan, Shivakumar Venkataram, Soriano-Mas Carles, Stern Emily R, Thomopoulos Sophia I, Thorsen Anders L, Vilajosana Enric, Walitza Susanne, Waller Lea, van der Werf Ysbrand D, van Wingen Guido, de Wit Stella J, ENIGMA-OCD consortium, Stein Dan J, Thompson Paul M, Vriend Chris, Veer Ilya M
Аннотация
METHODS: Individual participant data was uniformly processed using HALFpipe to extract statistical maps for response inhibition and error processing contrasts. Bayesian multilevel models were used to assess regional and whole-brain effects of OCD, and to examine the association between the OCD clinical profile and task-related activation.
RESULTS: Across inhibitory control tasks, both OCD and control participants showed robust activation in regions implicated in response inhibition and error processing. During response inhibition, compared to controls, adults with OCD showed stronger somatomotor cortex activation, while children with OCD showed stronger occipital cortex activation. Children with probable OCD from the ABCD cohort showed weaker activity in the frontoparietal network in the anterior insula/frontal operculum region. During error processing, relative to controls, adults with OCD showed weaker activation in fronto-striatal regions, while children with OCD showed stronger activation in frontoparietal and attention networks. Greater OCD symptom severity was associated with weaker task-related activation in adults and stronger activation in children during response inhibition.
CONCLUSION: Case-control differences in brain activation during inhibitory control varied by age group and task contrast. Symptom severity emerged as the main clinical correlate of activation during inhibition, suggesting that inhibitory control deficits in OCD may be both state-dependent and developmentally specific.