Journal of the Pediatric Infectious Diseases Society · 2026
Serum Procalcitonin and Outcomes in Severe Pediatric Pneumonia: A Secondary Analysis of An Observational Multicenter Study.
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Wong Judith Ju Ming, Yuliarto Saptadi, Rujirojampai Minchaya, Lee Pei Chuen, Liu Chunfeng, Dang Hongxing, Zhu Xuemei, Ong Jacqueline Soo May, Efar Pustika, Gan Chin Seng, Hui Alvin Wun Fung, Wang Justin Qi Yuee, Phan Phuc Huu, Fan Lijia, Choi Insu, Abbas Qalab, Samransamruajkit Rujipat, Cho Hwa Jin, Angurana Suresh Kumar, Xu Wei, Lee Jan Hau, MCI, on behalf of the Pediatric Acute and Critical Care Medicine Asian Network (PACCMAN)
Аннотация
BACKGROUND: Evidence on procalcitonin's role in the management of severe pediatric pneumonia is limited. This study aims to determine the association between procalcitonin and severity of illness in children with severe pneumonia.
METHODS: In this secondary analysis of a multi-center study in Asia, peak serum procalcitonin (measured within 5 days) was categorized into four groups (<0.5, 0.5-2.0, 2.0-10.0, >10.0 ng/mL). The primary outcome was mortality and secondary outcomes were acute respiratory distress syndrome (ARDS), septic shock, and multiorgan dysfunction. Area under the receiver operating curve (AUROC) analysis was used to assess the association of peak procalcitonin levels with primary and secondary outcomes.
RESULTS: Of 846 patients, 344 had early procalcitonin data. Mortality increased in groups with higher peak procalcitonin levels [8/162 (4.9%), 3/69 (4.4%), 8/55 (14.6%) vs. 11/58 (19.0%); p=0.002]. The proportion of patients with ARDS [23/162 (14.2%), 14/69 (20.3%), 10/55 (18.2%) vs. 25/58 (43.1%); p<0.001], septic shock [8/162 (4.9%), 10/69 (14.5%), 13/55 (23.2%) vs. 32/58 (55.2%); p<0.001], multiorgan failure [19/162 (11.7%), 13/69 (18.8%), 12/55 (21.4%) vs. 23/58 (39.7%); p<0.001] was also higher in groups with higher peak procalcitonin levels. The AUROC for procalcitonin showed moderate discrimination for mortality [0.69 (95%CI 0.58, 0.80)] and good discrimination for septic shock [0.81 (95%CI 0.76, 0.87)].
CONCLUSION: In critically ill children with severe pneumonia, higher serum procalcitonin was associated with mortality, ARDS, septic shock and multi-organ dysfunction. Procalcitonin alone is insufficient for clinical decision-making and should be interpreted alongside clinical assessment.
METHODS: In this secondary analysis of a multi-center study in Asia, peak serum procalcitonin (measured within 5 days) was categorized into four groups (<0.5, 0.5-2.0, 2.0-10.0, >10.0 ng/mL). The primary outcome was mortality and secondary outcomes were acute respiratory distress syndrome (ARDS), septic shock, and multiorgan dysfunction. Area under the receiver operating curve (AUROC) analysis was used to assess the association of peak procalcitonin levels with primary and secondary outcomes.
RESULTS: Of 846 patients, 344 had early procalcitonin data. Mortality increased in groups with higher peak procalcitonin levels [8/162 (4.9%), 3/69 (4.4%), 8/55 (14.6%) vs. 11/58 (19.0%); p=0.002]. The proportion of patients with ARDS [23/162 (14.2%), 14/69 (20.3%), 10/55 (18.2%) vs. 25/58 (43.1%); p<0.001], septic shock [8/162 (4.9%), 10/69 (14.5%), 13/55 (23.2%) vs. 32/58 (55.2%); p<0.001], multiorgan failure [19/162 (11.7%), 13/69 (18.8%), 12/55 (21.4%) vs. 23/58 (39.7%); p<0.001] was also higher in groups with higher peak procalcitonin levels. The AUROC for procalcitonin showed moderate discrimination for mortality [0.69 (95%CI 0.58, 0.80)] and good discrimination for septic shock [0.81 (95%CI 0.76, 0.87)].
CONCLUSION: In critically ill children with severe pneumonia, higher serum procalcitonin was associated with mortality, ARDS, septic shock and multi-organ dysfunction. Procalcitonin alone is insufficient for clinical decision-making and should be interpreted alongside clinical assessment.