Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
Successful Multidisciplinary Management of Acute-On-Chronic Liver Failure in a Twin Pregnancy Using Artificial Liver Support: A Case Report.
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Luo Pingping, Chen Weixia, Yu Lifei, Wang Lina
Аннотация
INTRODUCTION: Acute-on-chronic liver failure (ACLF) in pregnancy is a rare, life-threatening condition with high maternal and fetal mortality.
METHODS: We report a twin-pregnant patient with ACLF managed by a multidisciplinary team. Interventions included comprehensive medical therapy, seven sessions of artificial liver support (plasma exchange), symptom control, nutritional and psychological care, and prophylactic measures against mother-to-child transmission.
RESULTS: The patient successfully delivered healthy twins. Postdelivery, both infants tested negative for HBsAg and HBV-DNA, confirming effective prevention of vertical transmission. Maternal condition stabilized with treatment.
CONCLUSION: Multidisciplinary management incorporating artificial liver therapy and tailored obstetric care can achieve favorable maternal and neonatal outcomes in ACLF during twin pregnancy.
METHODS: We report a twin-pregnant patient with ACLF managed by a multidisciplinary team. Interventions included comprehensive medical therapy, seven sessions of artificial liver support (plasma exchange), symptom control, nutritional and psychological care, and prophylactic measures against mother-to-child transmission.
RESULTS: The patient successfully delivered healthy twins. Postdelivery, both infants tested negative for HBsAg and HBV-DNA, confirming effective prevention of vertical transmission. Maternal condition stabilized with treatment.
CONCLUSION: Multidisciplinary management incorporating artificial liver therapy and tailored obstetric care can achieve favorable maternal and neonatal outcomes in ACLF during twin pregnancy.