Hypersensitivity reaction after cyanoacrylate-adhesive closure of great saphenous vein requiring glue granuloma excision.

Hypersensitivity reactions after cyanoacrylate-adhesive closure of incompetent saphenous veins can range from mild and self-limiting to more severe. In the mild form, they can present as phlebitis-like reactions that are transient and resolve with antihistamines and oral corticosteroids. Although severe reactions are still rare, they have been described several times in the literature before. We describe the case of a foreign body reaction after cyanoacrylate-adhesive closure of a great saphenous vein leading to glue extrusion requiring surgical excision. Consideration of individual patient and anatomic factors is important when deciding on the appropriate method for varicose vein ablation.