[The clinical significance of serotonin antagonists].

Issuing from the physiological role of the serotonine, the possible significance of this biogenic amine for the pathogenesis of cardiovascular diseases is discussed. From this are derived indications for the use of serotonine antagonists. At present, of these ketanserine is regarded as the best investigated substance. The results of the hitherto performed clinical studies justify the application in hypertension. In contrast to this the assessment of the clinical and therapeutic value in chronic arteriosclerotic occlusive disease at stage II according to Fontaine and in Raynaud's syndrome is rendered difficult.