Group B Streptococcus serotype-specific IgG immunity in mother-newborn dyads in South Asian and African countries: a multicountry study, 2016-2018.
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Kwatra Gaurav, Izu Alane, Mukendi Christian, Dhar Nisha, Ali Musa Mohammed, Akaba Godwin, Ahmed Zabed, Beck Manisha Madhai, Barsosio Hellen Cherono, Berkley James A, Chaka Tolossa E, Cossa Anélsio, Chakraborty Sowmitra Ranjan, Cutland Clare L, Dorji Phurb, Islam Maksuda, Keita Adama Mamby, Mwakio Stella, Mwarumba Salim, Medugu Nubwa, Lema Feleke Belachew, Obaro Stephen, Olateju Eyinade K, Sigaúque Betuel, Sow Samba O, Saha Samir K, Santhanam Sridhar, Sharma Ragunath, Simoes Eric A F, Sahni Rani Diana, Tapia Milagritos D, Veeraraghavan Balaji, Madhi Shabir A
Аннотация
METHODS: We conducted a multi-country, cross-sectional study among pregnant women without HIV-1 infection and their newborns across six African (South Africa, Kenya, Mozambique, Ethiopia, Mali, Nigeria) and three South Asian countries (Bhutan, Bangladesh, India). Maternal and cord blood samples were collected at delivery and analyzed using a multiplex immunoassay for serotype-specific CPS GBS IgG.
RESULTS: We analyzed 2,293 mother-newborn dyads. Maternal serotype-specific CPS-IgG concentrations varied significantly by country and serotype. Most women had detectable serotype-specific IgG antibodies, with >95% of participants having detectable antibodies against serotypes II, III, and IV across most countries, whereas lower proportions were observed for serotypes Ib and V. Serotype II demonstrated the most efficient transplacental transfer ratios with GMRs ranging from 0.80 (95% CI 0.74-0.85) in South Africa to 1.16 (95% CI 1.07-1.27) in Bhutan. Transfer was generally lower for other serotypes, particularly in Kenya, where GMRs ranged from 0.51 (95% CI 0.46-0.58) for serotype IV to 0.81 (95% CI 0.73-0.91) for serotype II. The proportions of newborns above the serotype-specific serological thresholds of risk reduction (SToRR) varied widely across countries ranging from 10.0%-56.8% for serotype Ia and 13.5%-68.0% for serotype III. Bangladesh consistently had the highest maternal and cord blood antibody concentrations whereas Bhutan and Ethiopia had the lowest.
CONCLUSIONS: Marked geographic and serotype-specific variability in maternal and neonatal GBS IgG concentration was observed across South Asian and African countries. These findings provide important information on baseline naturally acquired immunity and transplacental antibody transfer, which may inform the evaluation and implementation of maternal GBS vaccines in diverse populations.