Respirology (Carlton, Vic.) · 2026
Low-Dose CO2 Inhalation to Improve Oxygenation and Exercise Capacity at High Altitude: A Double-Blind Pilot Study.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Liang Shanfeng, Catcheside Peter, Wellman Andrew, Wu Luguang, Wang Lishuang, Steier Joerg, He Baiting, Schwartz Alan R, Eckert Danny J, Luo Yuanming
Аннотация
BACKGROUND AND OBJECTIVES: Inhalation of CO2 might improve hypoxia and exercise performance at high altitude by increasing respiratory drive and offsetting hypocapnia. We developed a novel device with minimized dead space and respiratory resistance to deliver CO2 at precise concentrations at high altitude.
METHODS: Twenty-eight healthy lowlanders (aged 38 ± 13 years, male/female: 13/15) were recruited and taken from an altitude lower than 500 m to 4505 m in Tibet by airplane. A randomized double-blind study was performed to compare blood gases and endurance shuttle walk test (ESWT) during inhalation of ambient air and 2.5% CO2 using the device. Arterial blood gases were measured within 4 h of arrival at high altitude, and the ESWT was performed on the morning of the second day after arrival.
RESULTS: Both PaCO2 and PaO2 during CO2 inhalation were significantly higher than during ambient air breathing (PaCO2: 33.5 ± 4.0 vs. 31.4 ± 3.5 mmHg; PaO2: 42.3 ± 5.8 vs. 34.9 ± 5.1 mmHg; all p < 0.001) at high altitude. Compared with ambient air, CO2 inhalation was also associated with a lower heart rate. There was no difference in pH and respiratory rate during inhalation of 2.5% CO2 and ambient air. ESWT distance during inhaling 2.5% CO2 was significantly longer than that during inhalation of ambient air at high altitude (960.0 (713.2-1464.8) m vs. 677.0 (554.2-1026.9) m, p < 0.001).
CONCLUSIONS: Our results suggest that inhalation of 2.5% CO2 increases both PaO2 and exercise performance at 4505 m.
TRIAL REGISTRATION: ClinicalTrials. gov identifier: NCT05798416.
METHODS: Twenty-eight healthy lowlanders (aged 38 ± 13 years, male/female: 13/15) were recruited and taken from an altitude lower than 500 m to 4505 m in Tibet by airplane. A randomized double-blind study was performed to compare blood gases and endurance shuttle walk test (ESWT) during inhalation of ambient air and 2.5% CO2 using the device. Arterial blood gases were measured within 4 h of arrival at high altitude, and the ESWT was performed on the morning of the second day after arrival.
RESULTS: Both PaCO2 and PaO2 during CO2 inhalation were significantly higher than during ambient air breathing (PaCO2: 33.5 ± 4.0 vs. 31.4 ± 3.5 mmHg; PaO2: 42.3 ± 5.8 vs. 34.9 ± 5.1 mmHg; all p < 0.001) at high altitude. Compared with ambient air, CO2 inhalation was also associated with a lower heart rate. There was no difference in pH and respiratory rate during inhalation of 2.5% CO2 and ambient air. ESWT distance during inhaling 2.5% CO2 was significantly longer than that during inhalation of ambient air at high altitude (960.0 (713.2-1464.8) m vs. 677.0 (554.2-1026.9) m, p < 0.001).
CONCLUSIONS: Our results suggest that inhalation of 2.5% CO2 increases both PaO2 and exercise performance at 4505 m.
TRIAL REGISTRATION: ClinicalTrials. gov identifier: NCT05798416.